You Position: Home > Paper

Genetic variation of IL-28B is associated with treatment response of patients with chronic hepatitis C

( views:251, downloads:100 )
Author:
No author available
Journal Title:
Chinese Journal of Experimental and Clinical Virology
Issue:
4
DOI:
10.3760/cma.j.issn.1003-9279.2012.04.018
Key Word:
肝炎,丙型,慢性;白细胞介素类;多态性,单核甘酸;复发;Hepatitis C,chronic;Interleukins;Polymorphism,single nucleotide;Recurrence

Abstract: Objective To explore the effect of IL-28B variation on the response of patients with chronic hepatitis C virus (HCV) infection to therapy.Methods A total of 220 patients with chronic hepatitis C (CHC) were prospectively treated with pegilated interferon (peg-IFN) in combination with ribavirin (RBV) for 48 weeks.After completing the therapy,the patients were followed-up for 24 weeks and the therapeutic effectiveness was evaluated.The rs8099917 was identified from each cohort.The IL28B genotype was compared in hepatitis C patients to assess the effect of single nucleotide polymorphism (SNP)on different treatment response.Result The proportion of the rs8099917 1T,TG,and GG genotypes was 71.4%,25.0%,and 3.6% in sustained viral response (SVR) group; 15.8%,60.5%,23.7% in null response (NR) group; 38.1%,52.3%,9.6% in relapse (RP) group.There was a statistically significant difference in the genotype among SVR,NR and RP groups (P <0.001,Chi-square test).NR vs.SVR (TG vs.TT:OR =7.67,95% CI:2.91-20.56,P<0.001).RP va.SVR (TG vs.11:OR=3.10,95% CI:1.14-6.36,P < 0.01 ).Conclusions The genotypes of IL-28 B ( rs8099917 ) is closely related to the effectiveness of peg-IFN-α/RBV therapy,and it is an important predictive factor before treatment in patients with chronic hepatitis C.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn