Abstract: Objective To understand the hemagglutination inhibition antibody level in patients with influenza A H1N1.Methods Sera from 28 patients with influenza A H1N1 at different time points after illness onset were collected and measured by hemagglutination inhibition assay.Results The serum hemagglutination inhibition antibody tilers at 1,5,15,22,37,49 and 58 days after illness onset were 5.36、9.39、39.02、57.99、137.92、55.19 and 57.99 respectively.The top geometric mean tiler of hemagglutination inhibition antibody was 148.55.The antibody seroconversion rate and seroprotection rate were occurred in 96.4% (27/28)of patients.Conclusion The patients with influenza A H1N1 have effective immune response.