Abstract： Objective The aim of this study is to investigate the possible associations of chemokines IP-10,Rantes and oxidative stress in chronic hepatits B (CHB).Methods 70 CHB patients and 10 healthy controls were enrolled in the study.Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-γ-inducible protein-10 (IP-10) and regulated on activation normal T-cellexpressed and secreted (Rantes) and oxidative stress parameters (glutathione,GSH; glutathione disulfide,GSSG).Correlationship were analyzed by Spearman's rank correlation.Result The levels of IP-10 and Rantes were higher in CHB patients than healthy controls,and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT).The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls,and GSH and GSH/GSSG were negatively correlated with ALT.The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.Conclusion Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.