Bioinformatic analysis of genes related to Alzheimer's disease
- Author:
- No author available
- Journal Title:
- Chinese Journal of Neuromedicine
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1671-8925.2012.08.003
- Key Word:
- 阿尔茨海默病;基因芯片;生物信息学;Alzheimer's disease;DNA microarray;Bioinformatics
Abstract： Objective To investigate the genes associated with Alzheimer's disease (AD) by bioinformatics methods to provide new thoughts for basic research and clinical treatment of AD.Methods The microarray data of AD-related genes were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String,KEGG and Panther databases.Results Of all the 34 differentially expressed genes,25 were found to encode proteins with interactions; they referred to multiple biological pathways,biological processes and molecular functions.Conclusion The pathogenesis of AD involves multiple genes,especially genes with Ca2+ signaling,and investigations of these genes may provide valuablc insights into the mechanism of AD.
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