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Perspective of statins in the prevention and treatment for Alzheimer's disease

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF NEUROMEDICINE

Issue:: 5

DOI:: 10.3760/cma.j.issn.1671-8925.2011.05.027

Key Word:: 阿尔茨海默病;他汀类药物;动脉粥样硬化;危险因素;Alzheimer's disease;Statins;Atherosclerosis;Risk factor

Abstract： @@ 老年性痴呆主要由两类病因构成:AD和血管性痴呆(vascular dementia,VaD),其中AD约占50%~60%,VaD约占10%~20%,其他为混合性痴呆(MID)或其他痴呆[1].我国最新的流行病学调查表明,65岁以上人群痴呆的发病率约为10%,并以每5年增加1倍的速度递增,在80岁以上人群中可高达40%,且与国外资料相比,其发病率和疾病种类构成比均无国籍和人种的明显差异[2].鉴于老年性痴呆对个人、家庭、社会的巨大危害性,将老年性痴呆的防治提高到国家战略性高度已迫不容缓.

Reference

[1]张桂云,潘玉红.阿托伐他汀治疗血管性痴呆患者认知功能的疗效观察[J].2007,(8).
[2]付剑亮,孙晓江.脂代谢与痴呆[J].2007,(3).
[3]林岩,李焰生.他汀类药物与痴呆[J].2005,(9).
[4]赵水平,吴军,谭利明,等.他汀类药物对急性脑梗死的抗炎作用[J].2005,(40).
[5]Chengxuan Qiu,Bengt Winblad,Laura Fratiglioni.The age-dependent relation of blood pressure to cognitive function and dementia[J].2005,4(8).
[6]Beach T,Li R,Lindholm K,etc.Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients[J].2004,101(10).
[7]Vladimir P,Stanislav M,Helena Z,etc.The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain.[J].2009,74(1).
[8]Zhang ZX,Tang MN,Zahner GE,etc.Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu.[J].2005,62(3).
[9]Burgut T,Weksler ME,Relkin NR,etc.18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.[J].2009,30(11).
[10]Haag MD,Hofman A,Koudstaal PJ,etc.Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.[J].2009,80(1).
[11]D L, Sparks,Y M, Kuo,A, Roher,etc.Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.[J].2000,903.
[12]Elaine K Perry,Felix Potocnik,Piero Antuono,etc.Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors[J].2008,7(9).
[13]Mucke L,Roberson ED.100 years and counting: Prospects for defeating Alzheimer's disease[J].2006,314(5800).
[14]Kawarabayashi T,Ikeda M,Matsubara E,etc.Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls.[J].2008,1219(0).
[15]Cramer C,Langa KM,Haan MN,etc.Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.[J].2008,71(5).
[16]Canevari L,Clark JB.Alzheimer's disease and cholesterol: the fat connection.[J].2007,32(4/5).
[17]Ronald B, DeMattos,Kelly R, Bales,David J, Cummins,etc.Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.[J].2002,295(5563).
[18]Carlsson CM,Gleason CE,Hess TM,etc.Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease.[J].2008,13(2).
[19]段迪,凌迎春,周月琴.血管性痴呆及阿尔茨海默病患者血清甘油三酯和总胆固醇的变化[J].2009,(2).
[20]Hull M,Bradt B,Streit W,etc.Inflammation and Alzheimer's disease.[J].2000,21(3).
[21]L M, Refolo,M A, Pappolla,J, LaFrancois,etc.A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.[J].2001,8(5).
[22]Sonnen JA,Shofer JB,Petrie EC,etc.Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.[J].2007,69(9).
[23]Regan CM,Lemere CA,Selkoe DJ,etc.Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.[J].2008,14(8).
[24]Boche D,Bayer A,Yadegarfar G,etc.Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial.[J].2008,372(9634).
[25]Esh C,Roher AE,Rahman A,etc.Atherosclerosis of cerebral arteries in Alzheimer disease.[J].2004,35(11 Suppl.1).
[26]Delgado-Rodriguez M,Berciano J,Combarros O,etc.Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease.[J].2008,117(1).
[27]Rosenmann H,Rosenmann D,Abramsky O,etc.Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy.[J].2009,68(3).
[28]Ridker P. M.,Rifai N.,Pfeffer M. A.,etc.Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein[J].1999.