Lecithin-cholesterol acyltransferase gene 511C/T polymorphism is associated with cerebral hemorrhage

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Author:
HOU Rong-yao(Department of Neurology, Affiliated Haici Hospital, School of Medicine,Medical College of Qingdao University, Qingdao 266033, China)
ZHU Xiao-yan()
GUO Rui-you(Department of Neurology, Affiliated Haici Hospital, School of Medicine,Medical College of Qingdao University, Qingdao 266033, China)
XU Hong-wei()
XIAO Bo()
YANG Qi-dong()
TANG Bei-sha()
Journal Title:
CHINESE JOURNAL OF NEUROMEDICINE
Issue:
Volume 10, Issue 02, 2011
DOI:
10.3760/cma.j.issn.1671-8925.2011.02.003
Key Word:
Lecithin;cholesterol acyltransferase;Cerebral hemorrhage;Polymorphism,single nucleotide;High-density lipoprotein cholesterol

Abstract: Objective To explore the distribution of lecithin cholesterol acyltransferase (LCAT)gene 511C/T polymorphism in Chinese Han population and the association of its polymorphism with the occurrence of cerebral hemorrhage (CH). Methods The LCAT gene 511C/T polymorphism was identified by PCR, single-strand conformation polymorphism (SSCP) and DNA sequencing in 150 patients with CH and 122 age- and gender-matched healthy controls. Results The 511 situs of the fourth extron in LCAT gene existed polymorphism; C/T in this situs of both groups satisfied Hardy-Weinberg equilibrium. The CT genotype frequency (3.3%) and T allele frequency (1.7%) in patient group were not significantly higher than those (1.6%, 0.8%, respectively) in controls (P>0.05).The level of high-density lipoprotein cholesterol (HDL-C) in 511CC subgroup ([1.44±0.42] mmol/L) was significantly higher than that in 511CT subgroup ([1.06±0.30] mmol/L) of patient group (P<0.05).Conclusion The LCAT gene 511C/T polymorphism is not possibly a predisposing factor of CH in Chinese Han population. T allele frequency might be connected with the metabolism of HDL-C.

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