Effect of rotating magnetic field on pain threshold in rats' spinal cord:an analysis from processing time and angular velocity

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Author:
AN Shu-kang(Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
CHEN Zhong(Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
ZHOU Chu-song(Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
JIN An-min(Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
YANG Shao-an(Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
Journal Title:
CHINESE JOURNAL OF NEUROMEDICINE
Issue:
Volume 9, Issue 03, 2010
DOI:
10.3760/cma.j.issn.1671-8925.2010.03.005
Key Word:
Rotary magnetic field;Angular velocity;Processing time;Pain threshold

Abstract: Objective To observe the effects of rotating magnetic field on the tail-flick latency (TFL)and mechanical withdrawal threshold(MWT)of rats and analyze it from processing time and angular velocity.Methods Forty-eight female SD rats were randomly assigned to 8 groups(n=6),which would be determined by 8 different time points(before treatment,treating for 10,20,30 and 60 min,10,20 and 30 min after treatment).The magnetic plate rotated near the lumbar of the rat at an angular velocity of 7300 r/min and the TFL and MWT with yon Frey hair test were determined at each time point.The second experiment was carried out on 40 female rats at an angular velocity of 6300,6800,7300 and 7800 r/min,respectively;TFL and MWT were determined 30 min after treatment.The data were statistically analyzed.Results The first experiment was concluded as follows:compared with that before treatment,TFL was statistically increased at treating for 10,20,30 and 60 min(P<0.05).The TFL gradually became shorten after the treatment,but it was still significantly longer 10 and 20 min after the treatment as compared with that before treatment(P<0.05).MWT increased significantly at treating for 30 and 60 min,and 10 min after treatment as compared with that before treatment(P<0.05).The second experiment showed that TFL significantly went up as the angular velocity increased(P<0.05).Significantly difference on MWT was found between the angular velocity of 7800 and 6300 r/min.Conclusion Pain threshold can be increased by rotating magnetic field following the increase of processing time and the angular velocity at a certain range,indicating that the rotating magnetic field might be a potential non-invasive pain alleviating method.

  • [1]李路明,郝红伟.植入式神经刺激器的现状与发展趋势[J].中国医疗器械杂志,2009,33(2):107-111.
  • [2]毕得,张小云,苏湘鄂,等.旋转恒定磁场对大鼠血清中铁代谢相关蛋白的影响[J].现代生物医学进展,2009,9(2):240-242.
  • [3]李英女,杨宁江,张长民.超工频交变衰减磁场镇痛消炎效果的实验与临床研究[J].生物磁学,2002,2(1):26-27.
  • [4]张威,何建华.高旋交变磁场改善膝骨性关节患者步行能力的疗效观察[J].中国康复,2008,23(2):234-235.
  • [5]张桂莲,郭梅凤,程向晖.旋磁场对大鼠肝、心组织中SOD、MDA和NO的影响[J].中华物理医学与康复杂志,1995,27(6):375.
  • [6]陈仲,靳安民,刘成龙,等.大鼠腰椎磁力线切割阻断缩足反射的实验研究[J].中华神经医学杂志,2008,7(4):361-363.
  • [7]沃格尔.杜冠华译.药理学实验指南-新药发现和药理学评价[M].北京:科学出版社,2001:489-491.
  • [8]Sakura S,Kirihara Y,Muguruma T,et al.The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats[J].Anesth Analg,2005,101(5):541-547.
  • [9]Kirihara Y,Saito Y,Sakura S,et al.Comparative neurotoxicity of intrathecal and epidural lidocaine in rats[J].Anesthesiology,2003,99(5):961-968.
  • [10]Vavken P,Arrich F,Schuhfried O,et al.Effectiveness of pulsed electromagnetic field therapy in the management of osteoarthritis of the knee:a meta-analysis of randomized controlled trials[J].J Rehabil Med,2009,41(6):406-411.
  • [11]Av S,Evcik D.The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis:a randomized,placebo-controlled trial[J].Rheumatol Int,2009,29(6):663-666.
  • [12]Savich ML.On the absence of the effect of strong constant magnetic field on isolated membrane preparetions Na+-K+-ATPase[J].Biofizika,1984,29(1):171-173.
  • [13]江长层,王振刚,丁红卫,等.稳态磁场对小鼠脑突触小体膜的影响[J].北京医科大学学报,1994,26(2):142-143.
  • [14]闫秀英,韩丽莎,许志华,等.旋磁场对血清SOD活力、铜蓝蛋白活性及MDA含量的影响[J].中华物理医学杂志,1997,19(2):115-116.
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