Abstract： Objective To analyze the expressions of E-cadherin and β-catenin in meningioma by immunohistochemistry for further understanding of biological behaviors of meningiomas. Methods The specimens included in this study were collected form 49 meningioma cases. EnVision was used in immunohistochemieal staining. The results were graded depending on the positive rate and intensity of the immunoreactivity. E-cadherin and β-catenin in meningiomas were analyzed in relationship with WHO2000 grading and invasion. Results The positive rates of E-adhesion in meningioma WHO Ⅰ,Ⅱ,Ⅲ were 92.69%, 33.33% and 0, respectively (P<0.05). The positive rates of β-catenin in meningioma WHO Ⅰ,Ⅱ,Ⅲ were 82.93%, 33.33% and 20.00%, respectively (P<0.05). The positive rate of E-adhesion in meningiomas without invasion (94.12%) was higher than that in ones with invasion (46.67%), and the difference was of statistical significance (P<0.05). The difference in positive rate of β-catenin was statically significant between meningiomas without invasion (88.24%) and the ones with invasion (33.33%, P<0.05). Conclusions The levels of E-adhesion and β-catenin are in close correlations with the WHO2000 grading of meningioma. In the atypical or anaplastic meningiomas, the expressions of E-adhesion and β-catenin are lower significantly. The levels of E-adhesion and β-catenin are also in close correlations with the aggressiveness of meningioma. The lower the expressions of E-adhesion and β-catenin, the more invasive meningioma will possibly be.