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The relationship between the biological behavior of gliomas and the state of adjacent fiber tracts

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NEUROMEDICINE
Issue:
4
DOI:
10.3760/cma.j.issn.1671-8925.2008.04.004
Key Word:
神经胶质瘤;弥散张量成像;白质纤维束;病理学;分子生物学;Glioma;Diffusion tenor imaging;Fiber tract;Pathology;Biology

Abstract: Objective To study the relationship between the biological behavior of gliomas and the state of adjacent fiber tract. Methods Regular MRI and DTI were performed in 24 patients with histologically confirmed brain gliomas. The fiber tracts adjacent gliomas reconstructed with 3-dimensional, the state of fiber tracts were evaluated with displaced, infiltrated or destroyed. Reflection the infiltration of glioma of MMP-9 、CD44 and the proliferative activity of VEGF and Ki-67 expression were evaluated by SP immunohistochemical staining method in surgical specimens. Results The expression of VEGF or Ki-67 was higher in high grade gliomas than low grade (P<0.05) and a negative correlation (P>0.05) between MMP-9 or CD44 expression and the grade of gliomas was found. The states of fiber tracts were damaged greatly in the periphery of high grade gliomas than low grade (P<0.05).Further, the states of fiber tracts were destroyed heavily in the periphery of gliomas that had higher expression of VEGF or Ki-67 (P<0.05). But there were poor correlation (P>0.05) between MMP-9 or CD44 expression and the state of fiber tracts adjacent to gliomas. Conclusions The grade of and proliferation of gliomas can influence the state of fiber tracts in the periphery of gliomas but the infiltration did not. It was helpful to estimate the biological behavior of gliomas on imagines and useful in deciding the therapeutic regimen.

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