Study on hypersynchronous discharge based on the cross-correlation analysis of EEG phases of temporal lobe epilepsy

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Author:
CUI Lin-yang(Department of Neurology,General Hospital,Tianjin Medical University, Tianjin Neurological Institute,Tianjin 300052,China)
TIAN Xin(Department of Neurology,General Hospital,Tianjin Medical University, Tianjin Neurological Institute,Tianjin 300052,China)
Journal Title:
CHINESE JOURNAL OF NEUROMEDICINE
Issue:
Volume 7, Issue 03, 2008
DOI:
Key Word:
Epilepsy,temporal lobe; Electroencehalogram; Hypersynchronous discharge;Cross-correlation coefficients

Abstract: Objective To study the bilateral temporal EEG phases of the temporal lobe epilepsy (TLE) patients to support that the hypersynchronous discharge is one of the causes of seizure.Methods Thirty human subjects participated in the study.TLE group(n=20)were TLE patients with left epileptogenic focus.Control group(n=10)were healthy Volunteers.Bilateral temporal EEGs were recorded with MR-95 Recorder(Oxford Company).Four Ag/Agcl electrodes were placed bilaterally on the subject's temporal areas, the distance of any adjacent electrodes was 20 mm. The phases of these EEGs were extracted with Hilbert transform. We compared cross-correlation coefficients of all subjects.Statistical analysis was carried out with SPSS 10.0. Results The statistical analysis of the mean EEG phases cross-correlation coefficients between adjacent recording electrodes showed that there was significant difference in the left and right temporal areas between the TLE group and the control group (P<0.01,P<0.05),and also significant difference between left(epileptic focus)and right(non-focus)temporal areas in the TLE group (P<0.05),while there was no significant difference between left and right temporal areas in the control group.Maximum phases cross-correlation coefficients were situated at adjacent recording electrodes in the control group, while 37.5% were separated in the TLE group.Conclusions There were the occurrences of hypersynchronous discharge in the epileptic focus and inferior hypersynchronous discharge in the non-focus.

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