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The analysis on the relationship between expressions of ABCG2, VEGF, IGFBP-2 and EGFR in glioma tissue microarray and prognosis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.09.004
- Key Word:
- 神经胶质瘤;干细胞标志蛋白;血管内皮生长因子;胰岛素样生长因子结合蛋白;内皮细胞生长因子受体;组织芯片;预后因素
Abstract： 目的 探讨干细胞标志蛋白(ABCG2)、血管内皮生长因子(VEGF)、胰岛素样生长因子结合蛋白(IGFBP-2)和内皮细胞生长因子受体(EGFR)在胶质瘤中的表达及与预后的关系.方法 构建布有各级别人脑胶质瘤标本的组织芯片,进行ABCG2、VEGF、IGFBP-2和EGFR的EnVision法、SP法免疫组化染色,分析其在胶质瘤中的表达率,并根据随访资料对可能影响预后的因素进行统计学分析. 结果 ABCG2、VEGF、IGFBP-2和EGFR的阳性表达率在胶质瘤恶性度高低组之间存在显著差异(P＜0.05).Logistic回归单因素分析显示术前Karnofsky评分(KPS)、手术切除范围、病理级别、肿瘤大小、术后放疗以及ABCG2、VEGF基因的表达对3年生存率有意义.多因素分析结果显示术前KPS评分、手术切除范围、病理级别、术后放疗、ABCG2和VEGF基因的表达是影响病人预后的因素. 结论 ABCG2、VEGF、IGFBP-2和EGFR的阳性表达与胶质瘤恶性程度相关.术前KPS评分、手术切除范围、病理级别、术后放疗、ABCG2和VEGF基因的表达可作为考察胶质瘤患者预后情况的重要指标.
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