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Effects of buyang huanwu decoction on neurogenesis in rats after focal cerebral ischemia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.08.002
- Key Word:
- 脑缺血;神经元再生;补阳还五汤;中医药
Abstract： 目的 探讨补阳还五汤对局灶性脑缺血大鼠神经元再生的影响.方法 Wistar大鼠随机分为假手术组、模型组、补阳还五汤组,每组32只,模型组、补阳还五汤组采用大脑中动脉阻塞法复制脑缺血模型,假手术组仅切开皮肤、分离右侧颈总动脉即缝合,补阳还五汤组在造模后予以补阳还五汤灌服,每日一次;另设正常对照组8只,不做任何处理.大鼠于实验开始后第一周每日腹腔给予5-溴脱氧核苷一次,此后每周两次.分别于1、7、14、28 d时各处死8只大鼠(正常对照组为2只),观察大鼠神经功能,采用免疫组织化学法检测新生神经元数.结果 补阳还五汤能显著减轻神经功能缺损;缺血后每组大鼠脑内均有少量新生神经元,补阳还五汤组数量较多,在7、14、28 d与模型组比较,差异有显著性(P＜0.05或P＜0.01).结论 缺血后大鼠脑内存在有限的神经再生,补阳还五汤能增强此增生.
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