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Study on the cytokines of acute cerebral hemorrhage complicated with systemic inflammatory response syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.07.014
- Key Word:
- 脑出血;全身炎症反应;细胞因子
Abstract： 目的 探讨急性脑出血患者并发全身炎症反应(SIRS)后TNF-α、IL-10情况及其与多脏器功能障碍综合征(MODS)、死亡率的关系.方法 60例急性脑出血患者分为SIRS组(28例)、non-SIRS组(32例),分别于发病24 h内及3、7、14 d晨起空腹抽取静脉血3 mL,采用放射免疫法测定血清TNF-α、IL-10水平,并观察两组患者MODS的发生率、死亡率.结果 在不同的时间点,脑出血患者TNF-α差异有显著性(P=0.000);SIRS组在3 d、7 d时TNF-α达到高峰;与non-SIRS组比较,各时间点均以SIRS组的TNF-α较高(P=0.000).在不同的时间点,脑出血患者IL-10差异有显著性(P=0.000);SIRS组、non-SIRS组在3 d时IL-10达到高峰,以后随时问逐渐下降;与non-SIRS组比较.各时间点均以SIRS组IL-10较高(P=0.000).SIRS组10例出现MODS,non-SIRS组仪2例,两者差异存在显著性(P=0.004).SIRS组15例死亡,non-SIRS组仅3例,两者差异存在显著性(P=0.000).结论 TNF-α及IL-10参与了脑出血后SIRS的发生、发展过程,TNF-α和IL-10可作为预测MODS的早期指标.
- [1]R C, Bone,R A, Balk,F B, Cerra,etc.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.[J].1992,101(6).
- [2]王今达,王宝恩.多脏器功能失常综合征（MODS）病情分期诊断及严重程度评分标准[J].1995,(6).
- [3].各类脑血管疾病诊断要点[J].1996,(6).
- [4]D, Godoy,A, Boccio,N, Hugo.[Systemic inflammatory response syndrome and primary of spontaneous intracerebral haemorrhage].[J].1900,35(12).
- [5]李庆荣,龙治平.SIRS与MODS的相关性研究[J].2001,(13).
- [6]Gu, Yong,Kuida, Keisuke.Activation of interferon-... inducing factor mediated by interleukin-1... converting enzyme.[J].1997,275(5297).
- [7]B P, Giroir.Mediators of septic shock: new approaches for interrupting the endogenous inflammatory cascade.[J].1993,21(5).
- [8]Slowik A,Szczudlik A,Dziedzic T,etc.Asymmetrical modulation of interleukin-10 release in patients with intracerebral hemorrhage.[J].2003,17(6).
- [9]Szczudlik A,Dziedzic T,Slowik A,etc.Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in blood.[J].2002,33(9).
- [10]Xi G,Hua Y,Hoff JT,etc.Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation.[J].2006,58(3).
- [11]Moochhala S,Bhatia M.Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome.[J].2004,202(2).
- [12]T S, Huber,G C, Gaines,M B, Welborn,etc.Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm.[J].2000,13(6).