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Change in cerebral blood flow during selective head cooling in newborn piglets with hypoxia-ischemia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.06.003
- Key Word:
- 脑血流;亚低温;缺氧缺血
Abstract： 目的 探讨选择性头部亚低温对缺氧缺血新生猪脑血流的影响. 方法 生后7 d龄新生猪16头随机分为三组:缺氧缺血常温组(n=6)、缺氧缺血亚低温组(n=6)和正常亚低温组(n=4).采用双侧颈总动脉阻断和吸入6%的氧30min制备新生猪缺氧缺血性脑损伤模型.亚低温组鼻咽部温度分别降到35 ℃和32℃.常温组维持正常体温(39℃).采用彩色微球方法测定脑血流.结果 正常亚低温组35℃和32℃时全脑血流分别降低到基础值的74%和52%(P＜0.05),颞叶、顶叶、脑干和小脑降低较为明显.新生猪缺氧缺血后2 h、4 h和6 h全脑血流较缺氧缺血前降低,差异有显著性意义(P＜0.05);缺氧缺血后4 h局部脑血流均显著降低,缺氧缺血后6 h海马、纹状体及丘脑脑血流仍较低(P＜0.05).缺氧缺血新生猪亚低温治疗后,35℃和32℃时全脑血流、局部脑血流与常温组相应的时间点比较差异没有显著性意义. 结论 新生猪缺氧缺血后脑血流降低.选择性头部亚低温可以显著降低正常新生猪脑血流,但对缺氧缺血新生猪脑血流没有显著影响.
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