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Changes of ATP, ADP and monoamine neurotransmitters in brain of rat models of cerebral infarction sequela
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.02.005
- Key Word:
- 脑梗死后遗症;模型;ATP;ADP;单胺类神经递质
Abstract： 目的 研究脑梗死后遗症大鼠模型脑组织ATP、ADP及单胺类神经递质含量的变化.方法 建立脑梗死后遗症大鼠模型,用高效液相色谱(HPLC)法测定大鼠脑组织ATP、ADP及单胺类神经递质含量.结果 刺激组(SG)毛发相对黯淡无光、卷曲,精神萎靡,惊恐,消瘦,肢体无力,摄食减少,饮水减少,手术伤口愈合迟缓,符合中医脑梗死后遗症征候.正常组(NG)大鼠脑组织ATP、ADP含量显著高于SG组、术后不刺激组(NSG)(P＜0.01),同时NSG组大鼠脑组织ATP、ADP含量显著高于SG组(P＜0.05).SG组大鼠脑组织NE、DA和5-HT含量显著低于NG组(P＜0.01),NSG组(P＜0.05);NSG组大鼠脑组织DA含量显著低于NG组(P＜0.05). 结论 脑梗死后遗症大鼠由于能量代谢障碍而出现脑组织的ATP、ADP含量降低,并且伴有大脑释放单胺类递质增加及脑细胞内的单胺类递质含量减少,单胺类递质分泌增加又加重了脑组织的损伤,加剧ATP、ADP等能量物质代谢障碍,形成恶性循环.
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