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Researches on the effect of thrombospondin-1, CD36, TGF-β1 in pituitary adenomas
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1671-8925.2007.01.006
- Key Word:
- 凝血酶敏感蛋白-1;CD36;转化生长因子β1;垂体瘤
Abstract： 目的 探讨垂体瘤中凝血酶敏感蛋白-1(TSP-1)、CD36、转化生长因子β1(TGF-β1)的表达及其与肿瘤侵袭性的关系. 方法 取52例垂体瘤(侵袭性组24例,非侵袭性组28例)手术标本,采用RT-PCR检测TSP-1、CD36、TGF-β1的mRNA表达,Western blot方法检测TSP-1、TGF-β1蛋白表达,并分析其表达与垂体瘤侵袭性等因素之间的关系. 结果 与非侵袭组相比,侵袭组TSP-1 mRNA及蛋白表达较弱,TGF-β1 mRNA及蛋白表达则强于非侵袭性组(P＜0.05),两组间CD36 mRNA表达差异无显著性意义(P＞0.05).肿瘤的大小组间、各内分泌功能分型组间TSP-1、TGF-β1、CD36差异均无显著性意义(P＞0.05). 结论 TSP-1、TGF-β1 mRNA及蛋白表达与垂体瘤侵袭性密切相关,提示其可能在垂体瘤发生发展中起重要作用,并能影响垂体瘤的侵袭性.
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