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Effect on working memory by intracranial co-infusion of Aβ1-42 and thiorphan to establish AD model in Macaca Rhesus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1671-8925.2006.08.005
- Key Word:
- 恒河猴;工作记忆;AD;Aβ1-42
Abstract： 目的 观察Aβ1-42和thiorphan联合颅内给药后恒河猴工作记忆是否发生改变.方法 Wisconsin训练猴笼内用延迟反应的方法测试恒河猴的工作记忆,比较猴子在给药前后的10 s、30 s、60s的正确应答率.结果 给药前后恒河猴10 s、30 s、60 s的正确应答率无改变.结论 Aβ1-42和thiorphan联合颅内给药建立恒河猴AD模型,50 d内尚未观察到恒河猴工作记忆发生改变.
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