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Dynamic expression of ET mRNA on different cerebral region and myocardium at acute stage of intracerebral hemorrhage in experimental rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.11.003
- Key Word:
- 实验性脑出血;内皮素;基因表达
Abstract： 目的探讨内皮素(ET)在脑心综合征发病机制中的作用.方法利用组织原位杂交技术检测实验性脑出血大鼠的中枢心血管特定调节区域及心肌ETmRNA表达的动态变化,并对阳性反应物进行图像定量分析.结果实验性脑出血可迅速诱导ET基因在脑出血周围区、下丘脑、脑干、海马、心肌的异常表达.脑出血6 h即可见ET mRNA表达上调,到24 h达高峰,72 h时段虽略有减少,但仍高于正常水平.同时心肌的ET表达增多.结论脑出血周围区及中枢心血管调节区域的ET过多释放,这可能是脑心综合征的病理基础之一.
- [1]温怀凯,倪莉,应斌宇,等.脑卒中患者血浆ET及CGRP含量变化的临床分析[J].2003,(4).
- [2]包新民,舒斯云著.大鼠脑立体定位图谱[M].1991.
- [3]吴卫平.脑缺血和再灌注后脑组织内皮素-1基因表达及丹参的影响[J].1996,(3).
- [4]D A, Greenberg,J, Chan,H A, Sampson.Endothelins and the nervous system.[J].1992,42(1).
- [5]龙洁.脑心综合征[J].1997,(11).
- [6]A, Hemsén,J M, Lundberg.Presence of endothelin-1 and endothelin-3 in peripheral tissues and central nervous system of the pig.[J].1991,36(1).
- [7]Kimihiro Yamashita,Yasufumi Kataoka,Yasuko S. Yamashita,etc.Glial Endothelin/Nitric Oxide System Participates in Hippocampus Ca1 Neuronal Death of Shrsp Following Transient Forebrain Ischaemia[J].1995,22(1).
- [8]唐朝枢,李兆萍,樊贵,等.内皮素对离体大鼠心肌细胞的影响[J].1992,(1).
- [9]F P, Nath,A, Jenkins,A D, Mendelow,etc.Early hemodynamic changes in experimental intracerebral hemorrhage.[J].1986,65(5).