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The plasticity of hippocampus in hippocampal kindled rats and the pathogenicity to epilepsy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.10.003
- Key Word:
- 电点燃;海马;可塑性
Abstract： 目的观察大鼠海马快速电点燃模型海马结构的可塑性改变,探讨其与癫痫发作的关系.方法24只Wistar大鼠右侧海马植入双极电极,平分为2组:对照组和电刺激组,观察动物发作行为,记录脑电发放,行右侧海马部尼氏体、胶质纤维酸性蛋白(GFAP)和脑源性神经营养因子(BDNF)染色.结果与对照组相比,癫痫发作组出现明显的神经元缺失、胶质细胞增生和BDNF表达上调.结论本模型中海马结构的可塑性改变可促进癫痫发作,是慢性癫痫得以维持和发展的结构基础.
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