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Study on the correlation of the changes of cerebral hemodynamics with intracranial pressure and cerebral perfusion pressure in patients with moderate and severe craniocerebral trauma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.09.005
- Key Word:
- 颅脑损伤;脑血流动力学;颅内压
Abstract： 目的探讨经颅多普勒(TCD)无创检测中、重型颅脑损伤患者的脑血流动力学变化与颅内压和脑灌注压的关系.方法前瞻性研究52例急性中、重型颅脑损伤患者的双侧大脑中动脉血流动力学状态,TCD检测脑血流动力学参数包括收缩期血流速度(Vp)、舒张期血流速度(Vd)、平均血流速度(Vm)、搏动指数(PI)、阻力指数(RI),持续监测颅内压(ICP)和脑灌注压(CPP)、平均动脉血压(MABP).对脑血流动力学参数、MABP与ICP、CPP进行相关性分析.结果PI、RI与ICP正相关系数分别为PI:r=0.881(P＜0.0001);RI:r=0.789(P＜0.0001),ICP和CPP与PI、RI、Vd、Vm、MABP多元逐步回归分析发现PI与ICP,CPP与PI、MABP关系最为密切(P＜0.0001).结论无创脑血流动力学检测可实时反映ICP和CPP的变化,可作为ICP和CPP监测的一种有效方法,具有无创、安全、价廉的特点,易于临床推广应用.脑灌注压
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