You Position: Home > Paper
Natural course of plasma Aβ variables during normal aging and their clinical values for diagnosing Alzheimer's disease
( views:289, downloads:20 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.08.003
- Key Word:
- 阿尔茨海默病;Aβ;酶联免疫吸附法
Abstract： 目的探讨血浆Aβ变量(Aβ40、Aβ42水平及其比值)在正常衰老和阿尔茨海默病(AD)疾病过程中的变化规律及对AD其诊断价值.方法双抗体夹心ELISA检测113例AD患者和205例不同年龄段健康者的血浆Aβ水平并分析其与AD临床的相关关系.结果在正常衰老过程中Aβ40和Aβ42水平呈现相反的变化曲线.AD患者Aβ40水平显著高于与其年龄匹配的正常老年组(P=0.002),而Aβ42水平却显著低于后者(P＜0.001),但在AD自然病程中Aβ变量没有明显改变.ROC分析表明:以aNC组Aβ比值的x+2s(15.9)为截断点时,其对AD诊断的敏感度和特异度分别为24%和96%.结论血浆Aβ变量呈现年龄和疾病相关性变化,其中Aβ比值有助于AD的临床诊断.
- [1]G, McKhann,D, Drachman,M, Folstein,etc.Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.[J].1984,34(7).
- [2]Tang MX,Stern Y,Schupf N,etc.Plasma A(beta)40 and A(beta)42 and Alzheimer's disease: relation to age, mortality, and risk.[J].2003,61(9).
- [3]Skovronsky DM,Lee VM,Pratico D.Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C.[J].2001,276(20).
- [4]Harigaya Y,Kanai M,Ikeda M,etc.The levels of cerebrospinal fluid Abeta40 and Abeta42(43) are regulated age-dependently.[J].2001,22(2).
- [5]Saido T,Ashe K,Younkin S,etc.Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.[J].2001,21(2).
- [6]Hyman BT,Irizarry MC,Fukumoto H,etc.Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.[J].2003,60(7).
- [7]Mehta PD,Patrick BA,Barshatzky M,etc.Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease.[J].2001,304(1).
- [8]John, Hardy,Dennis J, Selkoe.The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.[J].2002,297(5580).