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Change of telomerase activity in different organs of rats at different ages
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.06.005
- Key Word:
- 端粒酶;治疗性克隆
Abstract： 目的了解不同组织端粒酶活性随年龄变化的规律,为治疗性克隆核供体细胞的选择提供依据.方法采用PCR-ELISA法检测不同年龄SD大鼠皮肤、肌肉、骨髓、脑和睾丸组织的端粒酶活性.结果(1)随着年龄的增长,各组织端粒酶活性均呈下降趋势;(2)新生皮肤、肌肉和脑组织表达端粒酶活性,一月后则不再表达端粒酶活性;(3)一月至二年骨髓和睾丸组织均保持较高端粒酶活性.结论端粒酶活性表达程度与不同组织有关,骨髓和睾丸组织能维持较高端粒酶活性;骨髓组织中持续表达端粒酶活性的细胞可能是一种较好的核供体细胞.
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