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Microgyrus morphology and hippocampal mossy fiber sprouting in rats with focal cortical dysplasia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1671-8925.2005.04.003
- Key Word:
- 局灶性皮质发育障碍;小脑回;苔藓纤维,海马
Abstract： 目的探讨液氮损伤诱导局灶性皮质发育障碍大鼠海马形态学及苔藓纤维发芽的情况.方法实验随机分为正常对照组、假手术组和液氮损伤组,建立局灶性皮质发育障碍动物模型,察看其行为改变;采用常规HE染色、Nissl染色和Timm's硫化银组织化学方法染色,肉眼和光镜下观察大鼠脑皮质形态变化,光镜下评估海马苔藓纤维发芽情况,各组数据取苔藓纤维发芽评分,采用非参数秩和Kruskal-Wallis H检验,组间两两比较用Nemenyi法.结果液氮损伤组大鼠行为轻微改变,鼠脑嘴尾方向形成了一小的脑回,同侧海马CA3区有苔藓纤维发芽,而正常对照组和假手术组却没有.结论幼鼠早期液氮损伤可导致小脑回形成及海马CA3区苔藓纤维发芽.小脑回周围异常兴奋性突触环路和海马CA3区苔藓纤维发芽形成推测是局灶性皮质发育障碍导致癫痫发生的重要机制.
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