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Dynamic changes of activin A, inhibin A protein and activin receptor Ⅱ A mRNA in the mouse hippocampi following status epilepticus induced by pilocarpine
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-8925.2004.06.004
- Key Word:
- 癫痫持续状态;活化素A;抑制素A;活化素受体ⅡA
Abstract： 目的观察小鼠癫痫持续状态(status epilepticus,SE)后海马活化素A、抑制素A蛋白及活化素受体ⅡA mRNA表达的变化.方法采用匹鲁卡品诱导的SE小鼠模型,并以正常及未成SE的小鼠(NSE)作对照,分别应用Western blot与RT-PCR观察SE后活化素A与抑制素A蛋白及活化素受体ⅡAmRNA表达的动态变化.结果(1)正常小鼠海马活化素A含量很低;SE后3 h开始增高,6 h增高达显著性差异水平,24 h至高峰,48 h仍维持在较高水平,而NSE鼠活化素A表达无明显增加;(2)抑制素A蛋白SE后无明显增加,同正常及NSE小鼠比较无显著差异;(3)活化素受体ⅡAmRNA在SE后表达无明显变化.结论海马活化素A蛋白在匹鲁卡品诱导SE后明显上调,但活化素受体ⅡAmRNA及抑制素A蛋白无明显上调.
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