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Expression of matrix metalloproteinases(MMP-2、MMP-9)in human astrocytoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1671-8925.2004.04.005
- Key Word:
- 星形胶质细胞瘤;基质金属蛋白酶类;免疫组织化学
Abstract： 目的探讨基质金属蛋白酶(matrix metalloproteinases,MMP)与人脑星形胶质细胞瘤浸润性生长之间的关系,以及基质金属蛋白酶的阳性表达与星形胶质细胞瘤病理分级的关系.方法应用免疫组织化学染色法(SP法)检测44例人脑星形胶质细胞瘤组织中MMp-2、MMP-9的表达.结果Ⅲ、Ⅳ级中MMP-2、MMP-9蛋白的表达显著高于Ⅰ、Ⅱ级,而正常脑组织中无表达;在人脑星形胶质细胞瘤中MMP-2和MMP-9的表达之间无明显相关性.结论MMP-2、MMP-9的表达与星形胶质细胞瘤的恶性程度有关,其高表达可能与星形胶质细胞瘤的侵袭转移有关.
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