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The research progress of ornithine decarboxylase and its gene expression in human glioma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-8925.2003.06.022
- Key Word:
- 脑胶质瘤;鸟氨酸脱羧酶;基因表达;癌基因
Abstract： 鸟氨酸脱羧酶(ODC)是多胺合成的关键酶,ODC活性的改变可作为反映脑胶质瘤恶性程度的可靠的生物学标志;ODC基因的诱导与恶性肿瘤的发生及其浸润性密切相关,因而具备癌基因的特性.ODC抑制剂DFMO及针对ODC的抗酶蛋白(AZ)可能对脑胶质瘤有着潜在的治疗作用.
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