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Bone marrow stromal cells induced by neural stem cells to differentiate into neuron-like cells
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-8925.2003.06.003
- Key Word:
- 神经干细胞;骨髓基质细胞;分化;神经元
Abstract： 目的研究骨髓基质细胞向神经元样细胞分化的条件.方法神经干细胞诱导骨髓基质细胞向神经元样细胞分化,免疫细胞化学方法对分化的和未分化的细胞进行鉴定.结果神经干细胞可诱导骨髓基质细胞向神经元样细胞分化,分化的细胞表达神经元的标志物神经元特异性烯醇化酶(NSE).结论骨髓组织中存在能分化为神经元的干细胞,可能成为中枢神经系统自体移植的干细胞的来源.
- [1]杨立业,刘相名,孙兵,等.脂肪组织源性基质细胞表达神经元表型的实验研究[J].2002,(1).
- [2]杨立业,惠国桢.细胞移植治疗帕金森病[J].2002,(1).
- [3]杨立业,惠国桢,包大士,等.神经干细胞体外长期培养和外源基因表达[J].2002,(3).
- [4]杨立业,刘相名,惠国桢,等.丹参诱导鼠骨髓间充质细胞向神经元分化[J].2003,(1).
- [5]T R, Brazelton,F M, Rossi,G I, Keshet,etc.From marrow to brain: expression of neuronal phenotypes in adult mice.[J].2000,290(5497).
- [6]Mezey E.,Eglitis MA..Hematopoietic Cells Differentiate into Both Microglia and Macroglia in the Brains of Adult Mice[J].1997,94(8).
- [7]D J, Prockop.Marrow stromal cells as stem cells for nonhematopoietic tissues.[J].1997,276(5309).
- [8]Sanberg PR,Hazzi C,Saporta S,etc.Adult bone marrow stromal cells differentiate into neural cells in vitro.[J].2000,164(2).
- [9]Phinney DG,Prockop DJ,Kopen GC.Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.[J].1999,96(19).