You Position: Home > Paper
Bilateral deep brain stimulation at the subthalamic nucleus for treating idiopathic Parkinson's disease
( views:327, downloads:32 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROMEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1671-8925.2003.05.002
- Key Word:
- 原发性帕金森病;脑深部电刺激;丘脑底核
Abstract： 目的探讨双侧丘脑底核(STN)电刺激(DBS)对原发性帕金森病(PD)的治疗效果及手术方式.方法应用MRI扫描、手术计划系统及微电极导向技术进行靶点定位,对15例病人行双侧丘脑底核电极植入及锁骨下刺激器植入,术后1～2周打开刺激器,术后1个月到2年随访评价.结果全部15例病人术后肢体僵直、震颤及运动迟缓等症状明显缓解,UPDRS运动评分和日常生活能力评分均有显著下降(P＜0.01),左旋多巴服用量也有不同程度的减少,无严重或永久并发症发生.结论双侧STN电刺激手术治疗原发性PD,可全面改善病人症状,尤其是中线症状的改善更为明显;可通过调节刺激参数达到最佳治疗效果并避免副反应的发生;病人服药量减少,是一种安全有效的治疗方法.
- [1]C. Ardouin,B. Pillon,E. Peiffer,etc.Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: A consecutive series of 62 patients[J].1999,46(2).
- [2]A, Benazzouz,M, Hallett.Mechanism of action of deep brain stimulation.[J].2000,55(12 Suppl 6).
- [3]Lozano AM,Gross RE.Advances in neurostimulation for movement disorders.[J].2000,22(3).
- [4]Siebner HR,Ceballos Baumann-A,Standhardt H,etc.Changes in handwriting resulting from bilateral high-frequency stimulation of the subthalamic nucleus in Parkinson's disease.[J].1999,14(6).
- [5]P, Limousin,P, Pollak,A, Benazzouz,etc.Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.[J].1995,345(8942).
- [6]Koudsie A,Xie J,Krack P,etc.Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson's disease.[J].2000,55(12).
- [7]C, Gross,A, Rougier,D, Guehl,etc.High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases.[J].1997,87(4).