Relationship between β-fibrinogen promoter -455G/A (HaeⅢ) polymorphism and plasma fibrinogen of the patients with ischemic cerebrovascular disease

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Journal Title:
CHINESE JOURNAL OF NEUROMEDICINE
Issue:
Volume 2, Issue 04, 2003
DOI:
Key Word:
ischemic cerebrovascular disease;β-Fibrinogen Gene;plasma Fibrinogen

Abstract: Objective The -455G/A (HaeⅢ) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen.We determined whether it influences risk ofischemic cerebrovascular disease. Methods We accumulated 134 acute ischemiccerebrovascular disease (ICVD) cases and compared their -455G/A status with that in a control group (n=166). Furthermore,we analysed the β-fibrinogen gene -455A/G polymorphism for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ.Results Plasma fibrinogen was higher in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA(290 mg/dL), GG (298 mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353mg/dL) than in cases carrying the G allele: GA (287 mg/dL), GG (302 mg/dL) in the ICVD group. However, -455G/Apolymorphism of the β-fibrinogen gene was found not to be significantly associated with ICVD. Conclusion Although aminor effect on plasma fibrinogen cannot be excluded, -455G/A polymorphism of the β-fibrinogen gene does not appear tobe an important genetic determinant of ICVD.

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