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Progress in differentiation induction as a treatment for gliomas

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF NEUROMEDICINE

Issue:: 4

DOI:: 10.3760/cma.j.issn.1671-8925.2003.04.001

Key Word:: 胶质瘤;诱导分化;维甲酸;榄香烯

Abstract： @@ 诱导分化治疗(differentiation therapy)是肿瘤化学治疗的一个新领域.近年来,肿瘤分子生物学的研究表明,恶性肿瘤(包括脑胶质瘤)在发生学上是细胞分化紊乱的结果,其引起细胞分化阻滞的特异性基因改变在一定条件下是可逆的[1].

Reference

[1]钟春龙,罗其中,王勇,等.RAIFN-γ协同诱导分化对胶质瘤细胞增殖及Ki-67抗原表达的影响[J].2001,(4).
[2]周洪语,侯菊生,罗其中.榄香烯抗肿瘤作用机制的研究进展[J].2000,(5).
[3]A A, Levin,L J, Sturzenbecker,S, Kazmer,etc.9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.[J].1992,355(6358).
[4]侯菊生,徐英辉,陈玉仁,等.榄香烯治疗颅内恶性肿瘤临床研究（附30例报告）[J].1994,(4).
[5]H M, Beere,J A, Hickman.Differentiation: a suitable strategy for cancer chemotherapy?[J].1993,8(4).
[6]Gilles-Louis Defer,Homa Adle-Biassette,Frédéric Ricolfi,etc.All-trans retinoic acid in relapsing malignant gliomas: clinical and radiological stabilization associated with the appearance of intratumoral calcifications[J].1997,34(2).
[7]de The, H.,del Mar Vivanco-Ruiz, M..Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.[J].1990,343(6254).
[8]S J, Tang,L W, Ko,Y H, Lee,etc.Induction of fos and sis proto-oncogenes and genes of the extracellular matrix proteins during butyrate induced glioma differentiation.[J].1990,1048(1).
[9]James T. Rutka,Stephen J. De Armond,Jane Giblin,etc.Effect of retinoids on the proliferation, morphology and expression of glial fibrillary acidic protein of an anaplastic astrocytoma cell line[J].1988,42(3).
[10]B C, Devaux,J R, O'Fallon,P J, Kelly.Resection, biopsy, and survival in malignant glial neoplasms. A retrospective study of clinical parameters, therapy, and outcome.[J].1993,78(5).
[11]钟春龙.脑胶质瘤诱导分化治疗进展[J].1999,(6).
[12]X N, Li,Z W, Du,Q, Huang.Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells.[J].1996,84(5).
[13]Peter A. Steck,Azra Hadi,Reuben Lotan,etc.Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells[J].1990,42(2).
[14]Linskey ME,Gilbert MR.Glial differentiation: a review with implications for new directions in neuro-oncology.[J].1995,36(1).
[15]M.E Westarp,M.P Westarp,W Grundl,etc.Improving medical approaches to primary CNS malignancies-Retinoid therapy and more[J].1993,41(3).
[16]S E, Kaba,A P, Kyritsis,C, Conrad,etc.The treatment of recurrent cerebral gliomas with all-trans-retinoic acid (tretinoin).[J].1997,34(2).