Analysis of pathological characteristic in desmoplastic/nodular medulloblastoma
- Author:
- No author available
- Journal Title:
- Chinese Journal of Neurosurgery
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1001-2346.2012.10.021
- Key Word:
- 髓母细胞瘤;促纤维增生/结节型;病理学;Medulloblastoma;Desmoplastic/nodular;Pathology
Abstract： Objective To analysis clinic pathological characteristic of desmoplastic/nodular medulloblastoma (DNMB).Methods HE staining,Reticulin staining and immunohistochemisty staining were performed in 803 formalin fixed paraffin embedded tissues of medulloblastomas,to analysis the characteristic of DNMB.Results 103 cases (103/803) were identified DNMB with typical nodular,reticulin - free zones surrounded by densely intercellular reticulin fiber network.Intranodular cells were positive for NSE,Syn and Neu - N were found in DNMB,and Ki - 67 labeling indices were lower than Internodular regions.Reticulin staining showed positive for reticulin fibers in Internodular regions.Internodular regions of this DNMB showed strong cytoplasmic staining for GAB1 and filamin A,but negligible reactivity within nodules.Both Internodular and Intranodular regions showed cytoplasmic staining forβ- catenin.Conclusions DNMB is the distinct subtype of medulloblastoma with characteristic histological appearance.Mechanism of tumorigeness of DNMB is correlates of Sonic Hedgehog pathway.
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