Abstract： Objective To investigate the clinical value of early repair of skull defects in young children.Methods Skull defects in 19 children were repaired in early time,with titanium mesh individually designed by computer - assisted 3D modeling.The mean age was 5.8 years ( range,2 to 13years).The size of defects ranged from 2 cm × 5 cm to 12 cm × 12 cm.Repair of the skull defects was performed at least 3 months after the injury.Thin - section helical computed tomography (CT) scanning was performed before the operation.Computer - assisted 3D skull reconstruction was performed to generate a 3D model for a true - to - original repair of the skull of the patient.A 3D modeled titanium mesh completely matching the defect was designed and produced to repair the skull defect.Results All patients achieved excellent results.Primary healing occurred in all patients.The duration of follow - up ranged from 1 to 10 years.The titanium mesh was stably fixed in all patients,no patient experienced stabbing pain in the scalp,and no entrapment occurred.In all cases,no deformity in the skull were noted,the head and face were overall symmetrical.The rate of satisfactory outcome was 100％.Conclusions Early repair of skull defects in young children is benefit to children' s physical,psychological rehabilitation.By selecting the appropriate repair method,operations can be performed on children at the smallest age of 2.Computer- assisted 3D modeled titanium meshes can be applied for the treatment of skull defects in young children,and it has no significant effect on the growth of the skull.