Abstract： Objective To explore the methods of surgical treatment of low - grade glioma with secondary epilepsy.Method Video -EEG,magnetoencephalography(MEG) were performed to localizated the epileptogenic zone and domain in 13 patients,and stereotactic technology,ultrasound,electrocorticogram (EcoG) were performed intraoperative combinating to treat the low - grade gliomas that lead to epilepsy.Results The seizure was controlled while the tumor was resected and the neural function were protected in all patients.The clinical effect was significant.Conclusions The combination of multiple technology to localize the epileptogenic can resect the tumor or the epileptogenic zone maximum,reduce the injury of normal brain tissue,protect the cortex of brain domain,control the epileptic seizure and improve the patients' quality of life.