Abstract: Objective To investigate the value of combined monitoring of motor evoked potentials (MEP) and somatosensory evoked potentials (SEP) on the prevention of ischemic stroke in anterior circulation aneurysms surgery under total intravenous anesthesia. Method 47 patients of anterior circulation aneurysms were monitored SEP and MEP during the operation,the postoperative and preoperative neurological function variation and the relationship with monitoring outcome were compared.Result There was no significant change in neurological function in 91% patients(43/47).In 4/47 (9%) patients,we observed decreased nerve function with different degrees. Among these 4 patients,3 with motor evoked potentials and somatosensory evoked potentials amplitude declined>50% or disappeared simultaneously,moreover there was no recovery to baseline level after surgery,which were consistent with postoperative neurological deficit.Conclusion The changes of intraoperative monitoring indicators can be obtained for earlier indication of cerebral ischemia.The combined monitoring of SEP and TES-MEPs could improve the outcomes significantly for patients with aneurysms.It might be helpful to avoid postoperative ischemic stroke.