Study of the correlationship on the expression of TGF-β1 with communicating hydrocephalus
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1001-2346.2010.010.029
- Key Word:
- 转化生长因子β1;交通性脑积水;模型,动物;大鼠;Transforming growth factor-β1;Communicating hydrocephalus;Model,animal;Rat
Abstract： Objective To investigate the expression and signification of TGF-β1 in the kaolin-induced communicaing hydrocephalus rats. Methods Wistar rats were randomly divided into two groups, Group Kaolin, rats in which 50 μl volume of 2% Kaolin solution was injected into the cistema magna under microscope; and Group Saline, rats in which 50 μl volume of 2% saline was injected into the cisterna magna in the same way. Results Communicating hydrocephalus was induced in 28 rats and whose ventricular system expanded as time goes on. The cerebral ventricles were expanded,and intrameningeal fibrosis were shown in Group Kaolin. The expression of TGF-β1 in the cerebrospinal fluid (CSF) was higher in Group Kaolin than in Croup Saline. Conclusion These data suggest that there is relationship between the higher expressions of TGF-β1 with the development of communicating hydrocephalus in rats.
- [1].实验性脑积水大鼠脑中iNOS的表达及脑脊液中NO含量变化[J].2005,(9).
- [2]张庆华,张莉,孙涛,等.高岭土诱导大鼠交通性脑积水模型的建立及其特征[J].2008,(1).
- [3]唐健,毛伯镛,黄光富,等.犬脑积水后轴索损伤的神经微丝免疫组化研究[J].2005,(3).
- [4]S, Hakim,J G, Venegas,J D, Burton.The physics of the cranial cavity, hydrocephalus and normal pressure hydrocephalus: mechanical interpretation and mathematical model.[J].1976,5(3).
- [5]Wyss Coray T,Masliah E,Crews L.Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models.[J].2004,14(3).
- [6]Hinz B.Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis.[J].2009,11(2).
- [7]Tada T,Moinuddin SM.Study of cerebrospinal fluid flow dynamics in TGF-beta 1 induced chronic hydrocephalic mice.[J].2000,22(2).
- [8]Sival D,Bos A,Teelken A,etc.Cerebrospinal fluid obstruction and malabsorption in human neonatal hydrocephaly.[J].2006,22(10).
- [9]E, Galbreath,S J, Kim,K, Park,etc.Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus.[J].1995,54.
- [10]N, Hayashi,D W, Leifer,A R, Cohen.Chronologic changes of cerebral ventricular size in a transgenic model of hydrocephalus.[J].2000,33(4).