A clinicopathological analysis of 172 cases with intractable epilepsy
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1001-2346.2010.06.005
- Key Word:
- 癫痫;皮质发育不良;结节性硬化症;Epilepsy;Malformations of cortical development;Tuberous sclerosis
Abstract： Objective To discuss the clinicopathologic characteristics of surgically removed tissues in patients with intractable epilepsy. Methods From 2008 to 2009, the histological sections of 172 specimens of cerebral epileptogenic foci, which were acquired by surgery, were performed respectively by HE staining and immunohisto - chemical staining,the characteristics of clinical pathology were also analyzed. Results Of all the 172 cases, according to the pathological features of the epilepto -genic foci, there were 138 focal cortical dysp lasia (FCD) ,including 115 FCD ⅠB, 15 FCD ⅡA and 8 FCD ⅡB, 2 micro cortical dysplasia, 4 dysembryoplastic neuropithelial tumors,7 Rasmussen's encephalitis, 16 ulegyrias; 1 ganglioneuroma; 1 microgyria malformation, 1 vascular malformation, 1 hypothalamic hamartoma, 1 tuberous sclerosis. ConclusionFCD is the most commonly present in intractable epilepsy, and FCDⅠB is most common among the FCD.
- [1]李云林,栾国明,梁继军,等.灰质异位致癫痫的外科治疗及疗效分析[J].2005,(8).
- [2]丁成赟,赵永青,李志梅,等.448例症状性癫痫的病因分析[J].2006,(9).
- [3]赵国光,F.Cardinale,M.Cossu,等.局限性脑皮质发育不良继发顽固性癫痫的手术治疗[J].2006,(6).
- [4]梁树立,李安民,张志文,等.颞叶癫痫的临床分型与手术治疗[J].2005,(8).
- [5]蔡立新,李勇杰,张国君,等.以癫痫发作为惟一临床表现的颅内肿瘤的特点及手术治疗[J].2006,(12).
- [6]郭熙雄,陈谦学,田道锋,等.脑胶质瘤致癫痫因素临床分析[J].2007,(9).
- [7]周艳红,刘志雄,马志明,等.影响低度恶性胶质瘤癫痫预后的因素[J].2006,(23).
- [8]孙福海,朴月善,王玮,等.难治性癫痫相关脑肿瘤的临床病理学研究[J].2009,(3).
- [9]Prayson Richard,Rona Sabine,Nair Dileep,etc.Focal cortical dysplasias in eloquent cortex: functional characteristics and correlation with MRI and histopathologic changes.[J].2002,43(1).
- [10]R, Bauer,J, Dobesberger,C, Unterhofer,etc.Outcome of adult patients with temporal lobe tumours and medically refractory focal epilepsy.[J].2007,149(12).
- [11]Lee JS,Kim SU,Lee MC,etc.Pathophysiologic characteristics of balloon cells in cortical dysplasia.[J].2008,24(2).
- [12]Jackson GD,Dobyns WB,Kuzniecky RI,etc.Classification system for malformations of cortical development: update 2001.[J].2001,57(12).