Abstract： Objective To study the early diagnosis and combined treatment with chemotherapy and radiotherapy in intracranial basal ganglia germinoma. Method To analyze and judge the characteristics of age, sex, early clinical symptoms, systems, serology and photocopy (MRI, CT) of 25 patients with intracranial basal ganglia germinoma in order to get evidences of intracranial basal ganglia germinoma for early combined treatment. Results 4 cases were diagnosed as germinoma by pathology. The other 21 cases have been diagnosed early by analyzing and judging the characteristics of age, sex, early clinical symptoms, systems, serology and photocopy (MRI, CT). All cases were treated with chemotherapy and radiotherapy. All patients were followed-up for a period from 10 months to 7 years, with the average follow-up of 45 months. The tumor recurrence was not found. Conclusions The intracranial basal ganglia germinoma can be diagnosed earlier by careful clinical observation and comprehensive analysis and judgement, and satisfied results euuld be realized with the chemotherapy and radiotherapy.