Abstract： Objectives To explore the necessity, principles, selection of methods and materials of skull base reconstruction. To improve the efficacy of skull base surgery and decrease the surgery related complications. Methods 14 cases (3 cases of anterior skull base reconstruction and 11 cases of lateral skull base and related middle cranial fossa reconstruction) of skull base reconstruction were retrospectively analyzed. Titanium was used to repair the bony defect in 3 cases. Results All the cases were followed-up more than six months. Cerebral spinal fluid leakage and intracranial infection occurred in 1 patient in 3 weeks after operation and was cured with Kamofsky score of 40 after six months. Facial nerve injury occurred in 1 case and recovered completely after two months. The postoperative courses were uneventful in the else 12 cases without any surgery related complications such as cerebral spinal fluid leakage, infection or necrosis of transferred tissue etc. Conclusions Skull base reconstruction is integral to the skull base surgery, and the duraplasty in watertight style is the paramount part of the reconstruction procedures. The selection of the optimal reconstruction method and materials according to the tissue, size and site of defect with concerning not only functions but also cosmetics, can improve the efficacy of skull base surgery and decrease the surgery related compliations.