Abstract: Objective To identify radiological growth features of gliomas located in the paralimbic system and to present suggestions for clinical treatment. Method Eleven cases of gliomas located in the paralimbic system were recruited in the study. All of them were proved by pathology. The serial MRI in each patient was analyzed, focused on location change and growth tendency. MRI change was compared with that of clinical symptoms. MRI examination period was calculated and compared in low grade gliomas and high grade gliomas. Results On the sequential MRI, more than one anatomical units of paralimbic system were involved, with a ratio from 64% (7/11) to 100% (11/11). Clinically, 64% (7/11) of cases showed epilepsy at the onset. 91% (10/11) demonstrated aggravated symptoms before operation. MRI examination period showed no significant difference between 6 cases of low grade gliomas and 5 cases of high grade gliomas (P>0.05). Conclusions Treatment strategy of gliomas located in the paralimbic system should be made with a whole insight into the total anatomic region.