You Position: Home > Paper
Predictive chemotherapy according to O6-methylguanine-DNA methyltransferase protein expression for malignant gliomas
( views:116, downloads:92 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1001-2346.2007.02.005
- Key Word:
- 神经胶质瘤;化学疗法;O6-甲基鸟嘌呤-DNA甲基转移酶
Abstract： 目的 评价根据O6-甲基鸟嘌呤-DNA甲基转移酶(O6-methylguanine-DNA methyltransferase,MGMT)表达指导的恶性脑胶质瘤化疗的近期疗效和毒副反应.方法 经手术后病理确诊的恶性脑胶质瘤患者28例,用免疫组织化学方法检测肿瘤组织MGMT蛋白表达,对MGMT表达阳性者采用不含亚硝脲类和替莫唑胺的方案进行化疗,MGMT表达阴性者用药不受限.按WHO疗效评价标准评价近期疗效.不良反应评价按美国国立癌症研究所评价标准.结果 28例中有4例进行了两个方案化疗,共32化疗例次进入疗效评价.5例次完全缓解(complete response,CR),6例次部分缓解(partial response,PR),12例次稳定(stable disease,SD),9例次进展(progressive disease,PD).客观有效率(CR+PR)为35%,疾病控制率(CR+PR+SD)为73%.化疗的主要剂量限制性毒性为骨髓抑制.非血液学毒性主要为恶心呕吐和脱发.结论 对恶性脑胶质瘤病人在化疗之前检测MGMT蛋白表达,指导选择化疗方案,可以明显提高近期化疗疗效(有效率35%,传统亚硝脲类药物对恶性胶质瘤的有效率仅20%),毒副反应耐受性好.
- [1]祁震宇,惠国桢,张世明,等.一条人脑胶质瘤相关新基因的克隆与表达[J].2006,(2).
- [2]周晓平,卢旺盛,沈茜,等.TIMP-2对人脑胶质瘤U87体外侵袭力的抑制作用[J].2005,(1).
- [3]赵世光,滕雷,赵洪波,等.荧光引导鼠脑胶质瘤切除的实验研究[J].2006,(2).
- [4]黄强,浦佩玉,夏之柏,等.wt-p53基因联合HSV-TK/GCV对C6鼠胶质瘤杀伤作用的实验研究[J].2005,(5).
- [5]孟庆海,宫安静,李洛.树突状细胞活化的CTLs对神经胶质瘤的体外杀伤作用研究[J].2005,(7).
- [6]J R, Silber,M S, Bobola,S, Ghatan,etc.O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.[J].1998,58.
- [7]M. Bower,E. S. Newlands,N. M. Bleehen,etc.Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma[J].1997,40(6).
- [8]Z P, Chen,A, Malapetsa,A, McQuillan,etc.Evidence for nucleotide excision repair as a modifying factor of O6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines.[J].1997,52.
- [9]M. Sanson,A. Ameri,A. Monjour,etc.Treatment of recurrent malignant supratentorial gliomas with ifosfamide, carboplatin and etoposide: a phase II study[J].1996,32(13).