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Therapeutic effects of cinepazide maleate in craniocerebral injured patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1001-2346.2006.11.007
- Key Word:
- 马来酸桂哌齐特;颅脑损伤;治疗结果
Abstract： 目的 通过随机分组对照观察探讨马来酸桂哌齐特对颅脑损伤患者的治疗效果.方法 100例急性闭合性颅脑损伤患者,分为对照组和用药组,各50例病人.分析对比治疗后对照组和用药组的实验室各项检查指标:血液流变学,TCD检查结果等变化情况.并且对出院后3-6个月随访调查结果进行比较分析.结果 治疗后血液流变学检查中,用药组(马来酸桂哌齐特组)各项指标均低于对照组(P＜0.05).经颅多普勒检测结果显示:用药组的脑血流速度与对照组相比明显减慢(P＜0.05),血管痉挛得到缓解.对比两组出院后随访结果可以看出,用药组的GOS评分、KPS评分及Barthel指数预后明显好于对照组(P＜0.05).结论 初步证明急性颅脑损伤早期应用马来酸桂哌齐特可增加病变区的脑血流,改善微循环,改善颅脑损伤患者的预后.值得推广和进一步研究.
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