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A study of the effect of extrinsic ionized magnesium treatment in the patients with severe traumatic brain injury
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1001-2346.2006.02.004
- Key Word:
- 硫酸镁;重型颅脑创伤;丙二醛;预后;临床试验
Abstract： 目的探讨重型颅脑创伤(sTBI)患者硫酸镁治疗与患者血清丙二醛(MDA)含量及预后的关系.方法54例入选病例按入院先后随机分为治疗组和对照组.治疗组首先15min内静脉滴注2.5g硫酸镁,接着10g硫酸镁24h持续静滴,连用3天.对照组除硫酸镁外其他治疗完全相同.两组再按入院GCS评分分为特重组(GCS 3～5分)和重型组(GCS 6～8分),住院期间监测患者血清镁和MDA含量,伤后3个月纪录患者GOS评分.结果治疗组MDA含量低于对照组,特重组MDA含量高于重型组,血清镁离子含量低于重型组(P＜0.05).治疗组GOS评分好于对照组,但没有统计学意义.结论分sTBI患者,伤情越重,血清MDA含量越高,血清镁离子含量越低.硫酸镁能降低sTBI患者血清MDA含量,有改善预后的趋势.
- [1]J W, McDonald,F S, Silverstein,M V, Johnston.Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats.[J].1990,109(1-2).
- [2]Altura BT,Altura BM,Gebrewold A,etc.Low extracellular magnesium ions induce lipid peroxidation and activation of nuclear factor-kappa B in canine cerebral vascular smooth muscle: possible relation to traumatic brain injury and strokes.[J].2003,341(3).
- [3]Matz P,Lewen A,Chan PH.Free radical pathways in CNS injury.[J].2000,17(10).
- [4]R, Vink,T K, McIntosh,P, Demediuk,etc.Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma.[J].1988,263.
- [5]Santore MT,Schwartz NB,Dawson G,etc.Increased extracellular magnesium modulates proliferation in fetal neural cells in culture.[J].2001,127(2).
- [6]Kayali H,Kahraman S,Timurkaynak E,etc.Monitoring of serum ionized magnesium in neurosurgical intensive care unit: preliminary results.[J].2003,334(1).
- [7]Cernak I,Kotur J,Grbovic D,etc.Characterization of plasma magnesium concentration and oxidative stress following graded traumatic brain injury in humans.[J].2000,17(1).
- [8]Takeshi, Kato.[Role of magnesium ions on the regulation of NMDA receptor--a pharmacopathology of memantine].[J].2004,14(8).