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Investigation of pathology of neuron, expression of c-fos and c-jun in temporal lobe from temporal lobe epilepsy with hippocampal sclerosis

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NEUROSURGERY
Issue:
8
DOI:
10.3760/j.issn:1001-2346.2005.08.006
Key Word:
癫痫;颞叶;海马

Abstract: 目的研究海马硬化型颞叶癫痫(TLE)患者颞叶皮层神经元的变性凋亡以及c-fos、c-jun表达,并与海马的相应变化进行比较.方法14例颞叶和海马标本制成脑片后,用尼氏染色和TUNEL染色观察神经细胞变性和凋亡,并计数神经细胞数量;同时,研究c-fos和c-jun表达以反映癫痫发作对神经元损伤的程度和范围.结果颞叶皮层的神经细胞数量明显减少且形态异常,并有较多的凋亡细胞,伴有胶质细胞增生,而且有c-fos和c-jun的大量表达;其表现与海马的相应变化相似,但颞叶的胶质细胞增生更为明显.与对照组比较差异有统计学意义(P<0.01或P<0.05).结论除海马外,颞叶神经细胞和胶质细胞的病理改变可能参与海马硬化型TLE的发生和传播过程.

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