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The comparison of stimulation with ablation procedure in bilateral surgical treatment of Parkinson's disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1001-2346.2004.04.004
- Key Word:
- 帕金森病;脑深部刺激术;苍白球腹后部毁损术;丘脑腹中间核毁损术
Abstract： 目的比较脑深部刺激术和毁损术在双侧立体定向手术治疗帕金森病中的优缺点.方法 69例帕金森病病人进行了双侧手术治疗,其中同期双侧丘脑底核(STN)脑深部刺激术(DBS)11例,同期一侧苍白球腹后部毁损术(PVP),另一侧STN DBS 3例,分期一侧PVP或腹中间核(Vim)毁损术、另一侧STN或Vim DBS 9例;分期双侧PVP或Vim毁损术41例,同期双侧PVP 5例.平均随访9.3个月.结果 UPDRS评分显示刺激术和毁损术均能显著改善对侧肢体震颤、僵硬和运动迟缓症状,双侧刺激术还能改善步态和姿势症状,但双侧毁损术可加重语言、吞咽及流涎等症状,并发症较高.结论双侧DBS是具有双侧症状的帕金森病病人手术治疗的最佳术式,双侧毁损术并发症较高,应严格慎重采用.
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