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Microrecording techniques for targeting of ventrolateral thalamus in patients with Parkinson's disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1001-2346.2004.04.003
- Key Word:
- 立体定向;微电极记录;帕金森病;丘脑腹外侧核团;震颤细胞
Abstract： 目的研究帕金森病患者丘脑腹外侧核(VL)神经元电活动的特点,指导手术靶点的精确定位.方法 25例患者在接受立体定向丘脑手术时,应用微电极记录技术采集细胞的电活动资料,分析单细胞的电活动.结果共记录并甄别出258个神经元,44%的神经元簇状放电的节律与肢体震颤的节律高度相关(R=0.78),确认为震颤细胞,且多数位于Vim(n=75);11%的神经元放电对肢体运动有反应,确认为运动相关细胞.结论 VL中的细胞电活动有明确的特点,特别是Vim存在着大量的震颤细胞,为手术靶点的定位提供了重要指征.
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