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Clinical significance of deep brain stimulation in the treatment of Parkinson's disease on its second surgery

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF NEUROSURGERY
Issue:
4
DOI:
10.3760/j.issn:1001-2346.2004.04.002
Key Word:
帕金森病;毁损;脑深部电刺激术

Abstract: 目的探讨帕金森病(Parkinson's disease,PD)毁损术后再行脑深部电刺激术(deep brainstimulation,DBS)的可行性、靶点选择、术中电生理学特点和治疗结果.方法应用MRI和微电极记录技术进行靶点定位,对13例毁损术后的PD患者行DBS手术,其中7例曾行单侧苍白球毁损术(posteroventral pallidotomy,PVP),5例曾行单侧丘脑毁损术,1例曾行双侧丘脑及左侧苍白球毁损术.DBS的靶点包括单侧丘脑底核(subthalamic nucleus,STN)6例,单侧丘脑腹中间核(ventralintermediatenucleus,Vim)1例,双侧STN 4例,一侧STN及对侧苍白球(globus pallidusinternus,Gpi)2例.结果DBS对毁损术后的PD患者症状有不同程度的改善,其中单侧毁损术后行双侧DBS效果最明显.术后3个月的UPDRS运动及ADL评分较术前明显减少(P《0.05或0.01),美多巴的用量明显减少(P《0.05),无新的手术合并症.结论曾行毁损术的PD患者如面临二次手术,可以选择DBS手术,以双侧STN的DBS效果最好,并可减少药物用量,不加重原有的术后并发症.

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