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Malignant progression of ganglioglioma and analysis on its differentially expressed genes
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1001-2346.2004.03.002
- Key Word:
- 神经节细胞胶质瘤;cDNA微阵列;恶性进展
Abstract： 目的探讨神经节细胞胶质瘤恶性进展的分子变化,为进一步研究分子病因奠定基础.方法取同一患者不断恶化的3次手术标本,行cDNA微阵列检测,分析在不同阶段持续存在的差异表达基因.结果初发(WHOⅡ级)、复发(WHOⅢ级)和再发(WHOⅣ级)的标本与正常脑组织相比,差异表达基因共19条,其中下调者16条,上调者3条.在下调的基因中,功能明确者有抑制RAFl/MEK/ERKs激酶通路激活的磷酸酰乙醇胺结合蛋白,抑制肿瘤血管增生、侵袭,调控细胞凋亡的碳酰还原酶;抑制c-myc基因表达的肺库否样因子;参与人DNA切除修复的多聚酶ε.结论神经节细胞胶质瘤恶变过程中持续存在的分子变化,以抑制肿瘤增殖基因表达下调为主,其中RAF激酶抑制蛋白、DNA多聚酶ε和碳酰还原酶是参与细胞信号传导和DNA损伤修复等具重要功能的基因,值得进一步研究.
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