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The relevance of VEGF, bFGF and PTEN with glioma malignant degree and prognosis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1001-2346.2004.01.004
- Key Word:
- 神经胶质瘤;血管内皮生长因子;碱性成纤维细胞生长因子;抑癌基因;预后
Abstract： 目的研究血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、抑癌基因(PTEN)在胶质瘤的表达,并结合多种临床因素探讨其与肿瘤恶性程度及预后的关系.方法采用SABC免疫组化技术,检测50例胶质瘤VEGF、bFGF、PTEN的表达,并对可能影响预后的因素进行统计学分析.结果胶质瘤VEGF、bFGF、PTEN的表达在低级别组与高级别组之间存在显著差异(P＜0.05);Logistic逻辑回归单因素分析显示,患者年龄、肿瘤切除范围、恶性程度、KPS、术后化疗、术后放疗、肿瘤bFGF和PTEN表达对3年存活率有意义;多因素分析表明,肿瘤的恶性程度、术前患者KPS及PTEN基因的突变或缺失情况是影响胶质瘤患者预后的主要因素.结论VEGF、bFGF、PTEN在胶质瘤中的表达与其恶性程度相关,肿瘤的恶性程度、术前患者KPS及PTEN基因的突变或缺失情况可作为考察胶质瘤患者预后的独立指标.
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