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Implantable slow-release chemotherapeutic polymers for the treatment of malignant brain tumors
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1001-2346.2003.03.005
- Key Word:
- 多聚体缓释化疗;脑胶质瘤;临床试验
Abstract： 目的证明多聚体缓释化疗治疗高度恶性脑胶质瘤的有效性和安全性.方法设计随机临床对照实验计划,比较BCNU缓释片及安慰剂缓释片的疗效差异.结果 BCNU缓释片组病人的平均生存期为37周,安慰剂缓释片组病人的平均生存期为24周.术后6个月,安慰剂缓释片组中13(50%)名病人死亡,BCNU缓释片组中7(26%)名病人死亡(P＜0.05).结论术后肿瘤残腔置入BCNU缓释片能够延长病人生存时限,安全有效.
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