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The clinical preliminary report of Gamma knife radiosurgery for gliomas
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1001-2346.2002.02.005
- Key Word:
- 伽玛刀;胶质细胞瘤;治疗
Abstract： 目的评价伽玛刀对脑内胶质细胞瘤的治疗效果.方法自1996年11月至1999年12月对57例病理诊断明确的脑胶质瘤患者进行了伽玛刀治疗,其中男35例,女22例,年龄7～68岁,平均30.8岁.病变位于大脑半球27例,丘脑及基底节区22例,脑干2例,小脑2例.病理诊断:星形细胞瘤Ⅰ级7例,Ⅱ级5例,Ⅰ～Ⅱ18例,少枝胶质瘤4例,室管膜瘤2例,星形细胞瘤Ⅲ级2例,Ⅳ级2例,Ⅲ～Ⅳ级13例,胶质母细胞瘤4例.周边剂量为12～22Gy,平均为16.5Gy.结果随访时间为6至42个月,平均为23个月.36例低恶度胶质瘤的影像学复查结果:显效6例;有效14例;微效5例;无变化6例;恶化5例.有效率为55.6%.21例高恶度胶质瘤中2～3个月及远期影像有效率分别为66.7%和23.8%.6,12,24,36个月的存活率分别为:95.2%(20/21);81.0%(17/21);47.1%9(8/17)和33.3%(3/9).15例病人(26.3%)于治疗后12个月内出现放射性水肿.结论伽玛刀对体积较小,边界相对较清的低恶度胶质瘤的治疗是有效的,对高恶度胶质瘤在短期内可有效地杀死靶区内肿瘤细胞并延缓肿瘤的生长,但并不能有效地控制周边肿瘤细胞生长和复发.
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